Molecular Formula | C9H19NO5 |
Molar Mass | 221.25 |
Density | 1.137±0.06 g/cm3(Predicted) |
Boling Point | 372.1±32.0 °C(Predicted) |
pKa | 4.27±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.52 ml | 22.599 ml | 45.198 ml |
5 mM | 0.904 ml | 4.52 ml | 9.04 ml |
10 mM | 0.452 ml | 2.26 ml | 4.52 ml |
5 mM | 0.09 ml | 0.452 ml | 0.904 ml |
biological activity | Amino-PEG3-C2-acid is a degradable (cleavable) 4-unit PEG ADC linker for the synthesis of antibody-coupled drugs (ADC). Amino-PEG3-C2-acid is a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
target | Cleavable PEGs |
in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Bioactive Amino-PEG3-C2-acid is a degradable (cleavable) 4-unit PEG ADC linker used in the synthesis of antibody-coupled drugs (ADC). Amino-PEG3-C2-acid is a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
Target
Cleavable
PEGs
In vitro study
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.